Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis
نویسندگان
چکیده
منابع مشابه
Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis
PURPOSE Demonstrate unequivocally the generation of nitric oxide in experimental autoimmune uveoretinitis by electron spin resonance spectroscopy (ESR) using ferrous iron complex of N-methyl-D-glucamine dithiocarbamate, (MGD)(2)-Fe(2+), as a spin trap. METHODS Experimental autoimmune uveitis was induced in Lewis rats, and at the peak of the intraocular inflammation, the animals received intra...
متن کاملMouse models of experimental autoimmune uveitis.
The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of pathogenesis and test novel immunotherapeutic p...
متن کاملRodent models of experimental autoimmune uveitis.
The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides ...
متن کاملExperimental autoimmune uveitis: cellular immune responsiveness.
N. Y. Supported by Grant Award EY 00699 from the National Institutes of Health, Bethesda, Md. Presented in part before the Spring Meeting of The Association for Research in Vision and Ophthalmology, April 1979. Submitted for publication Nov. 19. 1979. Reprint requests: E. I. Anderson, Ph.D., Department of Ophthalmology, Columbia University College of Physicians & Surgeons, New York, N. Y. 10032.
متن کاملLow Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis
BACKGROUND Rapamycin, a potent immune modulator, is used to treat transplant rejection and some autoimmune diseases. Uveitis is a potentially severe inflammatory eye disease, and 2 clinical trials of treating uveitis with rapamycin are under way. Unexpectedly, recent research has demonstrated that low dose rapamycin enhances the memory T cell population and function. However, it is unclear how ...
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ژورنال
عنوان ژورنال: Korean Journal of Ophthalmology
سال: 2007
ISSN: 1011-8942
DOI: 10.3341/kjo.2007.21.1.21